Acute generalized exanthematous pustulosis
Acute generalized exanthematous pustulosis (AGEP) ose fa'alavelave fa'afuase'i o le pa'u lea i le 90% o mataupu e feso'ota'i ma le fa'aogaina o vaila'au. Acute generalized exanthematous pustulosis o lo'o fa'aalia i le oso fa'afuase'i o le pa'u e aliali mai i le averesi o le lima aso talu ona amata se vaila'au. O nei pa o pustules, o lona uiga o sina mumu paʻepaʻe poʻo le mumu mumu o le paʻu o loʻo i ai mea faʻafefe poʻo purulent (pus). O manu'a o le pa'u e masani ona fo'ia i totonu ole 1-3 aso talu ona tu'u le vaila'au fa'ama'i.
☆ I le 2022 Stiftung Warentest i'uga mai Siamani, o le fa'amalieina o tagata fa'atau i ModelDerm sa na'o sina maualalo ifo nai lo fa'atalanoaga telemedicine totogi.
Ua fa'afuase'i ona alia'e mai fa'alavelave fa'afuase'i o manu'a fa'asalalau ma erythema ma pustules.
References
Acute generalized exanthematous pustulosis (AGEP) ose pa'u e fa'ailogaina i tama'i patu'u ua tumu i le pa'u mumu. E masani ona tupu pe a inuina e se tasi ni vailaʻau, e pei o vailaʻau faʻamaʻi, ma vave ona sosolo i le tino. A uma ona taofi le faʻaosoina o vailaʻau, e masani lava ona alu ese faʻaʻailoga i totonu o le lua vaiaso, e masani ona tuua ai le paʻu o le paʻu. E ui lava e masani lava e le ogaoga ma fa'atapula'a ile pa'u, e mafai ona fa'ama'oti fa'atasi ma isi fa'alavelave tuga e pei o le Stevens-Johnson syndrome po'o le toxic epidermal necrolysis. Togafitiga o le tausiga lagolago muamua, ma o le faʻataʻitaʻiga mo le fofo atoatoa o le faʻamaʻi e masani ona lelei.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
O se alii e 76 tausaga le matua na sau i le potu faʻafuaseʻi ona ua suia lona paʻu i aso e lua ua tuanaʻi. Na maua e fomaʻi ni paʻu mumu ma sisi i luga o lona ogalaau ma lima ma vae. A o faagasolo pea le taimi, na pipii faatasi nei paʻu, ma na ia maua ai ni patupatu pei o pimple i vaega mumu. O su'ega na fa'aalia ai le maualuga o le toto pa'epa'e ma le tele o ituaiga e ta'ua o le neutrophils, ma fa'atupula'ia le maualuga ole C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
